反应详情

A mixture of 1-chloro-3-(4-methoxyphenyl)isoquinoline (0.79 g) obtained in Example 10-2, 1-(2-hydroxyethyl)piperazine (0.6 g), and potassium carbonate (0.83 g) was reacted in dimethylformamide (10 ml) at 100° C. for 6 hr. The reaction mixture solution was evaporated. Ethyl acetate and water were added to the resulting residue. The resulting organic layer was washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated, and the resulting residue was purified by silica gel column chromatography (methylene chloride/methanol system), to give the free compound of the title compound as a pale yellow oil.

1. customThe reaction mixture solution was evaporated
2. additionEthyl acetate and water were added to the resulting residue
3. washThe resulting organic layer was washed with water and brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated
6. customthe resulting residue was purified by silica gel column chromatography (methylene chloride/methanol system)