HRID1007073

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5281

Octadecanoic acid

C18H36O2

HCID12734

Diisopropylcarbodiimide

C7H14N2

HCID20088

Octadecanoic acid, hydrazide

C18H38N2O

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCCCC(=O)NNC(=O)CCCCCCCCCCCCCCCCC

HCID131724595

未命名化合物

收率 61.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To a solution of 20.0 g of stearic hydrazide, 21.0 g of stearic acid, 10.3 g of 1-hydroxybenzotriazole in 205.0 g of tetrahydrofuran was added 9.3 g of diisopropylcarbodiimide dropwise at room temperature, and the mixture was stirred for 3 hours under reflux. The deposited crystal was filtrated, and re-crystallized from isopropyl alcohol, to obtain 23.9 g of the intended compound.

WORKUP

后处理

temperatureunder reflux
filtrationThe deposited crystal was filtrated
customre-crystallized from isopropyl alcohol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d1c3627beb1f4bcca17e844550aa4171
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06794334B2
来源说明: uspto-grants-2004_09

反应 SMILES

[C:1]([NH:20][NH2:21])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[C:22]([OH:41])(=O)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39].ON1C2C=CC=C[C:46]=2N=N1.C(N=C=NC(C)C)(C)C>O1CCCC1>[CH3:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([NH:20][NH:21][C:22]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:46])=[O:41])=[O:19]