6-Methoxy-3-pyridinylamine → 6-Chloro-N-(6-methoxypyridin-3-YL)pyridine-3-carboxamide

HRID 1007223Notes

Reaction equation

HRID 1007223 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][N:3]=1.[NH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[N:16][CH:17]=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[N:16][CH:17]=2)=[O:7])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 811216-Methoxy-3-pyridinylamineHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 226689266-Chloro-N-(6-methoxypyridin-3-YL)pyridine-3-carboxamide

Procedure

The title compound was prepared from 6-chloronicotinoyl chloride and 5-amino-2-methoxypyridine as a pink solid as described in Example 1. 1H NMR (CDCl3): 8.87 (d, J=2.1, 1H), 8.28 (d, J=3.0, 1H), 8.20-8.17 (m, 1H), 7.99-7.96 (m, 1H), 7.67 (s, 1H), 7.49 (d, J=8.7, 1H), 6.81 (d, J=8.7, 1H), 3.95 (s, 3H).

Sources & evidence

ORD record
ord-10dfa030828b40d884740f7175c280c4
Source dataset
uspto-grants-2004_09
Patent number
US06794397B2

Reaction notes

Loading…