Hydrochloric Acid → HCID 178487835, compound

HRID 1007296Notes

Reaction equation

HRID 1007296 reaction equation
C(OC([NH:8][C:9]([NH:18][C@@H:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C@@H:20]1[NH:25][C:26]1[C:35]2[C:30](=[CH:31][CH:32]=[C:33]([O:36][CH3:37])[CH:34]=2)[N:29]=[C:28]([CH:38]=[CH:39][C:40]2[CH:45]=[CH:44][C:43]([Cl:46])=[CH:42][CH:41]=2)[N:27]=1)=[N:10]C(OC(C)(C)C)=O)=O)(C)(C)C.[ClH:47]>CO.C(Cl)(Cl)Cl.C(OCC)(=O)C>[ClH:46].[ClH:47].[C:9]([NH:18][C@@H:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C@@H:20]1[NH:25][C:26]1[C:35]2[C:30](=[CH:31][CH:32]=[C:33]([O:36][CH3:37])[CH:34]=2)[N:29]=[C:28]([CH:38]=[CH:39][C:40]2[CH:45]=[CH:44][C:43]([Cl:46])=[CH:42][CH:41]=2)[N:27]=1)(=[NH:8])[NH2:10]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 178487834HCID 178487834, compound

Product 1

HCID 178487835HCID 178487835, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 6212ChloroformSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 570 mg of cis-N-[N,N′-bis(tert-butoxycarbonyl)]amidino-2-[2-(4-chlorostyryl)-6-methoxyquinazolin-4-yl]aminocyclohexylamine in 8 mL of methanol and 8 mL of chloroform was combined with 5 mL of a 4N solution of hydrogen chloride in ethyl acetate, and reacted at 50° C. for 48 hours. After concentrating, crystallization are performed with ethyl acetate to obtain 310 mg of the desirable compound as pale yellow crystals.

Workup

  1. customreacted at 50° C. for 48 hours
  2. concentrationAfter concentrating
  3. customcrystallization

Sources & evidence

ORD record
ord-df045f5f89044bf89f9ac71edca24151
Source dataset
uspto-grants-2004_09
Patent number
US06794389B2

Reaction notes

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