Hydrochloric Acid → HCID 178478702, compound

HRID 1007312Notes

Reaction equation

HRID 1007312 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([C@@H:13]3[CH2:15][C@H:14]3[CH2:16][NH2:17])[N:10]=[CH:9]2)C=CC=CC=1.[ClH:30]>CO>[ClH:30].[ClH:30].[NH2:17][CH2:16][C@@H:14]1[CH2:15][C@H:13]1[C:11]1[N:10]=[CH:9][NH:8][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11057974HCID 11057974, compound

Product 1

HCID 178478702HCID 178478702, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of N-triphenylmethyl-4-(trans-2-aminomethyl-cyclopropyl)imidazole (100 mg, 0.26 mmol) in methanol (15 mL) was added 2N HCl solution (2.5 mL). The mixture was stirred at 60° C. for 2 hours and then concentrated. The resulting residue was extracted with ether (3×20 ml). The aqueous layer was lyophilized to give the product (47 mg, 83% yield).

Workup

  1. concentrationconcentrated
  2. extractionThe resulting residue was extracted with ether (3×20 ml)

Sources & evidence

ORD record
ord-b4fac3a3f7af44e7b443dac7fa09548e
Source dataset
uspto-grants-2004_09
Patent number
US06794405B2

Reaction notes

Loading…