Trifluoroacetic acid → (2-Nitro-4-trifluorobenzyl)acetic acid

HRID 1007375Notes

Reaction equation

HRID 1007375 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])([O-:3])=[O:2].FC(F)(F)C(O)=O>C(Cl)Cl>[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=[CH:6][C:5]=1[CH2:14][C:15]([OH:17])=[O:16])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69744202HCID 69744202, compound

Product 1

HCID 74433(2-Nitro-4-trifluorobenzyl)acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

16.7 g of tert.butyl 2-nitro-4-trifluoromethyl-phenylacetate and 50 ml of trifluoroacetic acid are dissolved in 50 ml of methylene chloride and stirred for 3 hours at ambient temperature. After elimination of the solvent the residue is taken up in petroleum ether/ether (10:1), suction filtered and dried in vacuo at 80° C.

Workup

  1. filtrationsuction filtered
  2. customdried in vacuo at 80° C.

Sources & evidence

ORD record
ord-e9fc63dba6d546939d8eb45e618e2542
Source dataset
uspto-grants-2004_09
Patent number
US06794395B1

Reaction notes

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