反应详情

500 mg of 5-(2,6-dichloro-4-nitrophenoxy)-3-isopropyl-1H-indole (Example I) are stirred with 6.18 g of tin(II) chloride dihydrate in 5 ml of NMP for 17 hours at 50° C. The solvent is removed in vacuo and the residue is taken up in ethyl acetate. The mixture is washed with saturated ammonium chloride solution and saturated sodium chloride solution, the organic phase is dried and the solvent is removed in vacuo. The product is precipitated with diethyl ether. By chromatographic purification (cyclohexane/ethyl acetate) of the solid, 174 mg of 3,5-dichloro-4-[(3-isopropyl-1H-indol-5-yl)oxy]aniline are obtained.

1. customThe solvent is removed in vacuo
2. washThe mixture is washed with saturated ammonium chloride solution and saturated sodium chloride solution
3. customthe organic phase is dried
4. customthe solvent is removed in vacuo
5. customThe product is precipitated with diethyl ether
6. customBy chromatographic purification (cyclohexane/ethyl acetate) of the solid, 174 mg of 3,5-dichloro-4-[(3-isopropyl-1H-indol-5-yl)oxy]aniline
7. customare obtained