反应详情

0.23 g (0.46 mmol) of ethyl cinnamate derivative from Example 13 are dissolved in 10 ml of dioxane, 4 ml of 1 molar sodium hydroxide solution are added and the mixture is stirred for 5 hours at room temperature. The reaction solution is acidified to pH 4 using 1N hydrochloric acid, treated with ethyl acetate and the aqueous phase is extracted a further two times with ethyl acetate. The combined organic phases are washed with sodium chloride solution, dried over sodium sulphate, filtered, concentrated and dried overnight in a high vacuum.

1. extractionthe aqueous phase is extracted a further two times with ethyl acetate
2. washThe combined organic phases are washed with sodium chloride solution
3. dry with materialdried over sodium sulphate
4. filtrationfiltered
5. concentrationconcentrated
6. customdried overnight in a high vacuum