Hydrochloric Acid → HCID 68800296, compound

HRID 1007888Notes

Reaction equation

HRID 1007888 reaction equation
[CH2:1]([N:3]([CH2:21][CH3:22])[CH2:4][CH2:5][O:6][CH2:7][CH2:8][C:9]1[CH:20]=[CH:19][C:12]2[S:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:11]=2[CH:10]=1)[CH3:2].[ClH:23]>C(O)C.C(OCC)(=O)C>[ClH:23].[CH2:21]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][O:6][CH2:7][CH2:8][C:9]1[CH:20]=[CH:19][C:12]2[S:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:11]=2[CH:10]=1)[CH3:22]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22666517HCID 22666517, compound

Product 1

HCID 68800296HCID 68800296, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

In 20 mL of ethanol is dissolved 1.90 g of 5-{2-[2-(diethylamino)ethoxy]ethyl}-benzo[b]thiophen-2-carboxylic acid, to which is added 5.6 mL of 1.38 mol/L solution of dry hydrogen chloride in ethanol. The resulting mixture is stirred at ambient temperature for 2 hours, and diluted with 20 mL of ethyl acetate. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 1.51 g of 5-{2-[2-(diethylamino)ethoxy]ethyl}-benzo[b]thiophene-2-carboxylic acid hydrochloride.

Workup

  1. filtrationThe deposited crystal is collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-7ad6bf76527d4a4ca64f3990f8f3b56a
Source dataset
uspto-grants-2004_09
Patent number
US06797726B1

Reaction notes

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