反应详情

Phosphorus oxychloride (3.1 ml) was added to 6-(benzyloxy)-7-methoxy-3,4-dihydro-4-quinazolinone (3.5 g) and diisopropylethylamine (11.5 ml). The mixture was refluxed for 20 min. The reaction solution was cooled to room temperature, and a 10% aqueous sodium hydroxide solution was then added to the cooled reaction solution, followed by extraction with chloroform. The organic layer was dried over sodium sulfate. The organic layer was filtered, and the solvent was then removed by distillation under the reduced pressure. The residue was dried through a vacuum pump to give 2.9 g (yield 72%) of the title compound.

1. temperatureThe mixture was refluxed for 20 min
2. extractionfollowed by extraction with chloroform
3. dry with materialThe organic layer was dried over sodium sulfate
4. filtrationThe organic layer was filtered
5. customthe solvent was then removed by distillation under the reduced pressure
6. customThe residue was dried through a vacuum pump