反应详情

温度

80 °C

A starting compound (N-{2-chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl) oxy]phenyl}-N′-propylurea, 80 mg), potassium carbonate (138 mg), and 4-chloromethylpyridine hydrochloride (41 mg) were dissolved in N,N-hr dimethylformamide (1 ml), and the solution was stirred at 80° C. for 3 hr. Water was added to the reaction mixture, and the mixture was extracted with chloroform-propanol (3/1). The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under the reduced pressure. The residue was purified by HPLC to give 71 mg (yield 71%) of the title compound.

1. extractionthe mixture was extracted with chloroform-propanol (3/1)
2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
3. customthe solvent was removed by distillation under the reduced pressure
4. customThe residue was purified by HPLC