反应详情

温度

80 °C

N-{2-Chloro-4-[(7-hydroxy-6-methoxy-4-quinolyl)-oxy]phenyl}-N′-(2,4-difluorophenyl)urea (55 mg), potassium carbonate (31 mg), and 3-picolyl chloride hydrochloride (22 mg) were dissolved in N,N-dimethylformamide (1 ml), and the solution was stirred at 80° C. for one hr. The solvent was removed by distillation under the reduced pressure. A saturated aqueous sodium hydrogencarbonate solution was added to the residue, and the mixture was extracted with chloroform. The chloroform layer was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was washed with ether to give 30 mg (yield 48%) of the title compound.

1. customThe solvent was removed by distillation under the reduced pressure
2. additionA saturated aqueous sodium hydrogencarbonate solution was added to the residue
3. extractionthe mixture was extracted with chloroform
4. dry with materialThe chloroform layer was dried over anhydrous sodium sulfate
5. customThe solvent was removed by distillation under the reduced pressure
6. washThe residue was washed with ether