反应详情

温度

90 °C

A stirred mixture of 2.0 g of methanesulfonic acid 2-methoxy-1-methoxymethyl-ethyl ester, 1.4 g of phenol and 2.8 g of powdered potassium carbonate in 50 mL of dry N,N-dimethylformamide was heated at 90° C. for 24 hours. After cooling, water was added at room temperature and the mixture extracted with diethyl ether. The combined ether extracts were washed with aqueous sodium hydroxide (2 N) and water, dried (sodium sulfate) and concentrated. The crude product (1.0 g) was used in the next step without further purification. EI-MS: 198 (M+).

1. temperatureAfter cooling
2. extractionthe mixture extracted with diethyl ether
3. washThe combined ether extracts were washed with aqueous sodium hydroxide (2 N) and water
4. dry with materialdried (sodium sulfate)
5. concentrationconcentrated
6. customThe crude product (1.0 g) was used in the next step without further purification