trans-Urocanic acid → HCID 178525356, compound

HRID 1008667Notes

Reaction equation

HRID 1008667 reaction equation
[CH:1]1[N:5]=[CH:4][NH:3][C:2]=1/[CH:6]=[CH:7]/[C:8]([OH:10])=[O:9]>[Pd].CO>[NH:5]1[CH:1]=[C:2]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])[N:3]=[CH:4]1

Participants

4

Reactant 1

HCID 736715trans-Urocanic acid2×

Product 1

HCID 178525356HCID 178525356, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Urocanic acid (3-(1H-imidazol-4-yl)-acrylic acid) (138 mg, 1 mmol) was placed in a round-bottom flask and dist MeOH was added thereto until urocanic acid was completely dissolved. To this solution, 10% Pd/C (30 mg) was added, replaced with H2 and stirred. After five hours, the loss of raw materials was confirmed, filtered, and the filtrate was concentrated under a reduced pressure to give the objective product.

Workup

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated under a reduced pressure
  3. customto give the objective product

Sources & evidence

ORD record
ord-007396ff74da472dba05514217e4cb3d
Source dataset
uspto-grants-2011_07
Patent number
US07973027B2

Reaction notes

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