tert-butyl N-(4-ethyl-5-methylsulfanyl-thiazol-2-yl)carbamate → HCID 86630962, compound
Reaction equation
C(OC(=O)[NH:7][C:8]1[S:9][C:10]([S:15][CH3:16])=[C:11]([CH2:13][CH3:14])[N:12]=1)(C)(C)C>Cl>[CH2:13]([C:11]1[N:12]=[C:8]([NH2:7])[S:9][C:10]=1[S:15][CH3:16])[CH3:14]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 30 °C
Procedure
The above prepared (4-ethyl-5-methylsulfanyl-thiazol-2-yl)-carbamic acid tert-butyl ester (1.067 g, 3.888 mmol) was treated with 20 mL of HCl (4 M in dioxane). After 48 h at RT the reaction mixture was evaporated to dryness and, since still some starting material was present, the procedure repeated, but this time the temperature was raised to 30° C. Careful evaporation and drying left 0.814 g of the title compound as hydrochloride.
Workup
- customAfter 48 h at RT the reaction mixture was evaporated to dryness
- customCareful evaporation
- customdrying
- waitleft 0.814 g of the title compound as hydrochloride
Sources & evidence
- ORD record
- ord-d1011213f0be4f55ad73edfaaed38614
- Source dataset
- uspto-grants-2011_07
- Patent number
- US07973051B2
Reaction notes
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