(4-Trifluoromethoxyphenoxy)-acetic acid tert-butyl ester → 2-(4-(Trifluoromethoxy)phenoxy)acetic acid

HRID 1009192Notes

Reaction equation

HRID 1009192 reaction equation
C([O:5][C:6](=[O:20])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]([F:19])([F:18])[F:17])=[CH:11][CH:10]=1)(C)(C)C>C(O)(C(F)(F)F)=O>[F:17][C:16]([F:18])([F:19])[O:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:7][C:6]([OH:20])=[O:5])=[CH:14][CH:13]=1

Participants

3

Reactant 1

HCID 57787045(4-Trifluoromethoxyphenoxy)-acetic acid tert-butyl ester

Product 1

HCID 6977052-(4-(Trifluoromethoxy)phenoxy)acetic acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

TFA (80 mL) was added to (4-trifluoromethoxyphenoxy)-acetic acid tert-butyl ester (25.8 g, 88 mmol). The mixture was stirred for three hours. The TFA was removed in vacuo affording the title compound as a white solid: MS (ESI-LCMS) for C9H6F3O4: 235 (M-H—).

Workup

  1. customThe TFA was removed in vacuo

Sources & evidence

ORD record
ord-791cd66cc89b4d09bf136f5323ef1ba6
Source dataset
uspto-grants-2011_07
Patent number
US07973061B2

Reaction notes

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