Hydrochloric Acid → HCID 67067275, compound

HRID 1009379Notes

Reaction equation

HRID 1009379 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][CH:6]([C:18]1[C:23]([F:24])=[CH:22][C:21]([F:25])=[CH:20][C:19]=1[F:26])[C:7]([NH:9][NH:10]C(OC(C)(C)C)=O)=[O:8]>C(O)(=O)C.C(OCC)(=O)C>[ClH:2].[Cl:2][CH2:3][CH2:4][CH2:5][CH:6]([C:18]1[C:19]([F:26])=[CH:20][C:21]([F:25])=[CH:22][C:23]=1[F:24])[C:7]([NH:9][NH2:10])=[O:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67067393HCID 67067393, compound

Product 1

HCID 67067275HCID 67067275, compoundYield 199.8%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 4 N hydrochloric acid in acetic acid (3 mL) was added to a solution of tert-butyl N′-[5-chloro-2-(2,4,6-trifluorophenyl)pentanoyl]hydrazinecarboxylate (333 mg) in ethyl acetate (3 mL), and the reaction solution was stirred at room temperature for 15 hours. The reaction solution was concentrated under reduced pressure to obtain 277 mg of the title compound. The property value of the compound is as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-75870ae580f947c1a4a915c8030bd154
Source dataset
uspto-grants-2011_07
Patent number
US07973033B2

Reaction notes

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