Hydrochloric Acid → HCID 86615151, compound

Temperature

130 °C

A 5 N hydrochloric acid solution (5 mL) was added to a solution of (2-chloroethoxy)-(6-chloropyridin-3-yl)acetonitrile (1.3 g) in THF (5 mL), and the reaction solution was stirred at 130° C. for two hours using a microwave reactor. The reaction solution was left to cool to room temperature. Then, a 5 N sodium hydroxide solution (10 mL) and diethyl ether were added to the reaction solution, and the aqueous layer was separated. A 5 N hydrochloric acid solution (5 mL) was added to the resulting aqueous layer to make the reaction solution neutral again, followed by extraction with methylene chloride twice. The resulting organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 565.1 mg of the title compound. The property value of the compound is as follows.

1. waitThe reaction solution was left
2. temperatureto cool to room temperature
3. customthe aqueous layer was separated
4. additionA 5 N hydrochloric acid solution (5 mL) was added to the resulting aqueous layer
5. extractionfollowed by extraction with methylene chloride twice
6. dry with materialThe resulting organic layer was dried over anhydrous sodium sulfate
7. concentrationconcentrated under reduced pressure

ORD record

ord-06dc66fafdd1445aa50cfe29d56d37f5

Source dataset

uspto-grants-2011_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07973033B2