反应详情

2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitro-1,3-thiazole (2.0 g), trifluoroacetic acid (20 ml) and thioanisole (2 ml) were stirred together at 65° C. for 90 minutes. The mixture was returned to room temperature, the solvent was distilled off under reduced pressure, 40 ml of methanol was added to the residue, and then sodium bicarbonate water was added until the foaming subsided. The precipitated solid was filtered out to obtain 1.4 g of a yellow powder.

1. customwas returned to room temperature
2. distillationthe solvent was distilled off under reduced pressure, 40 ml of methanol
3. additionwas added to the residue
4. additionsodium bicarbonate water was added until the foaming
5. filtrationThe precipitated solid was filtered out