Dimethyl Sulfoxide → HCID 22936690, compound

HRID 1010413Notes

Reaction equation

HRID 1010413 reaction equation
C1([O:7][C:8](=O)[NH:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]3[C:26]4[C:21](=[CH:22][C:23]([O:30][CH3:31])=[C:24]([C:27](=[O:29])[NH2:28])[CH:25]=4)[N:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[CH3:32])C=CC=CC=1.CS(C)=O.[CH2:38]([NH2:40])[CH3:39].O1CCCC1>C(OCC)(=O)C.O>[C:27]([C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:30][CH3:31])[N:20]=[CH:19][CH:18]=[C:17]2[O:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:8]([NH:40][CH2:38][CH3:39])=[O:7])=[C:11]([CH3:32])[CH:12]=1)(=[O:29])[NH2:28]

Participants

7

Reactant 4

HCID 679Dimethyl SulfoxideHCID 6341EthylamineHCID 8028TetrahydrofuranHCID 58931269HCID 58931269, compound

Product 1

HCID 22936690HCID 22936690, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

[4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-methyl-phenyl]-carbamic acid phenyl ester (65 mg) was added to dimethylsulfoxide (1.0 ml), and then an ethylamine-containing 2N tetrahydrofuran solution (0.37 ml) was added and the mixture was stirred for 5 minutes. Water and ethyl acetate were added to the reaction solution, and the precipitated crystals were filtered out to obtain the title compound (38 mg).

Workup

  1. additionwas added
  2. filtrationthe precipitated crystals were filtered out

Sources & evidence

ORD record
ord-4f0558b7dd554c1c9e54cf48c2ce5e5e
Source dataset
uspto-grants-2011_07
Patent number
US07973160B2

Reaction notes

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