Ethyl cyanoacetate → 3-Hydroxybenzaldehyde

HRID 1010528Notes

Reaction equation

HRID 1010528 reaction equation
C([O:3][C:4](=[O:8])[CH2:5][C:6]#[N:7])C.[C:9]([C:12]1C=CN=C[CH:13]=1)(=[O:11])[CH3:10]>>[C:4]([O-:8])(=[O:3])[CH3:5].[NH4+:7].[OH:11][C:9]1[CH:10]=[C:5]([CH:6]=[CH:13][CH:12]=1)[CH:4]=[O:8]

Participants

4

Reactant 2

HCID 7764Ethyl cyanoacetateHCID 142824-Acetylpyridine

Product 2

HCID 1013-HydroxybenzaldehydeHCID 517165Ammonium Acetate

Procedure

Analogously to Example 1a, 1.82 g of product is obtained from 7.57 g of ammonium acetate, 1.31 ml of cyanoacetic acid ethyl ester, 1.36 ml of 4-acetylpyridine and 1.5 g of 3-hydroxybenzaldehyde.

Sources & evidence

ORD record
ord-6a123124a2844c8f963de797195f8867
Source dataset
uspto-grants-2011_07
Patent number
US07977325B2

Reaction notes

Loading…