Pinacolone → 3-Hydroxybenzaldehyde

HRID 1010531Notes

Reaction equation

C([O:3][C:4](=[O:8])[CH2:5][C:6]#[N:7])C.[CH3:9][C:10](C)(C)[C:11](=[O:13])[CH3:12]>>[C:4]([O-:8])(=[O:3])[CH3:5].[NH4+:7].[OH:13][C:11]1[CH:12]=[C:5]([CH:6]=[CH:9][CH:10]=1)[CH:4]=[O:8]

Participants

Reactant 2

HCID 6416Pinacolone

HCID 7764Ethyl cyanoacetate

Product 2

HCID 1013-Hydroxybenzaldehyde

HCID 517165Ammonium Acetate

Procedure

Analogously to Example 1a, 814 mg of product is obtained from 5 g of ammonium acetate, 875 μl of cyanoacetic acid ethyl ester, 1.01 ml of 3,3-dimethyl-2-butanone and 1 g of 3-hydroxybenzaldehyde.

Sources & evidence

ORD record: ord-4ca9253c605043fabea9d8f2dc5f6b2a
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07977325B2

Reaction notes

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