Pinacolone → 3-Hydroxybenzaldehyde

HRID 1010534Notes

Reaction equation

HRID 1010534 reaction equation
C([O:3][C:4](=[O:8])[CH2:5][C:6]#[N:7])C.[CH3:9][C:10](C)(C)[C:11](=[O:13])[CH3:12]>>[C:4]([O-:8])(=[O:3])[CH3:5].[NH4+:7].[OH:13][C:11]1[CH:12]=[C:5]([CH:6]=[CH:9][CH:10]=1)[CH:4]=[O:8]

Participants

4

Reactant 2

HCID 6416PinacoloneHCID 7764Ethyl cyanoacetate

Product 2

HCID 1013-HydroxybenzaldehydeHCID 517165Ammonium Acetate

Procedure

Analogously to Example 1a, 750 mg of product is obtained from 5 g of ammonium acetate, 875 μl of cyanoacetic acid ethyl ester, 1.13 ml of 3,3-dimethyl-2-butanone and 1 g of 3-hydroxybenzaldehyde.

Sources & evidence

ORD record
ord-1e489f73d5af4ebfb0e59f1c9867dd97
Source dataset
uspto-grants-2011_07
Patent number
US07977325B2

Reaction notes

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