反应详情

温度

80 °C

1 ml of water, 1 g activated charcoal and 2.66 g (24 mmol) selenium dioxide was added to a solution of 1.65 g (6.00 mmol) N-(acetylphenyl)benzenesulphonamide in about 10 mL dioxane. The reaction mixture was stirred for approx. 4 d at 80° C. and then the solvent was eliminated using the rotary evaporator. The residue was dissolved in about 30 ml of ethanol and refluxed for approx. 4 h. The solvent was eliminated from the reaction mixture using the rotary evaporator, the residue was dissolved in about 100 mL ethyl acetate, washed about three times with 30 ml saturated aqueous sodium hydrogen carbonate solution, dried over sodium sulphate and the solvent was eliminated using the rotary evaporator. 0.917 g (2.73 mmol, 46%) N-[3-(2-ethoxy-2-hydroxyacetyl)-phenyl]-benzenesulphonamide were obtained as a yellow solid.

1. customthe rotary evaporator
2. dissolutionThe residue was dissolved in about 30 ml of ethanol
3. temperaturerefluxed for approx. 4 h
4. customthe rotary evaporator
5. dissolutionthe residue was dissolved in about 100 mL ethyl acetate
6. washwashed about three times with 30 ml saturated aqueous sodium hydrogen carbonate solution
7. dry with materialdried over sodium sulphate
8. customthe rotary evaporator