Benzoyl isothiocyanate → HCID 57813664, compound

HRID 1010645Notes

Reaction equation

HRID 1010645 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:13])[CH:5]=[C:6]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:7]=1.[C:14]([N:22]=[C:23]=[S:24])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[C:14]([NH:22][C:23]([NH:13][C:4]1[CH:5]=[C:6]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:7]=[C:2]([Br:1])[CH:3]=1)=[S:24])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 57813693HCID 57813693, compound

Product 1

HCID 57813664HCID 57813664, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To the solution of 3-bromo-5-pyrazol-1-yl-phenylamine (0.18 g, 0.76 mmol) in anhydrous acetone (5.0 mL) was added benzoylisothiocyanate (0.14 g, 0.83 mmol) and the reaction mixture was stirred at room temperature for 30 min. Acetone was distilled off and the crude residue was washed with hexane to obtain desired compound (0.27 g, 89%).

Workup

  1. distillationAcetone was distilled off
  2. washthe crude residue was washed with hexane

Sources & evidence

ORD record
ord-18cbabfc64b647299b8469b8255a1d4b
Source dataset
uspto-grants-2011_07
Patent number
US07977340B2

Reaction notes

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