Potassium Carbonate → 10-(3-hydroxypropyl)-5,8-Dioxa-10-azadispiro[2.0.4.3]undecane

HRID 1010796Notes

Reaction equation

HRID 1010796 reaction equation
[CH2:1]1[C:3]2([CH2:11][NH:10][CH2:9][C:4]32[O:8][CH2:7][CH2:6][O:5]3)[CH2:2]1.Br[CH2:13][CH2:14][CH2:15][OH:16].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[OH:16][CH2:15][CH2:14][CH2:13][N:10]1[CH2:11][C:3]2([CH2:1][CH2:2]2)[C:4]2([O:5][CH2:6][CH2:7][O:8]2)[CH2:9]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 123083-Bromo-1-propanolHCID 224172225,8-Dioxa-10-azadispiro[2.0.4.3]undecane

Product 1

HCID 1673828210-(3-hydroxypropyl)-5,8-Dioxa-10-azadispiro[2.0.4.3]undecane

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The compound (B) (100 mg) was mixed with 3-Bromopropanol (120 mg) and K2CO3 (120 mg) in Acetonitrile. The reaction was refluxed overnight and filtered; the filtrate was evaporated and purified on silica gel column to give the titled product. Mass: (M+1), 214

Workup

  1. temperatureThe reaction was refluxed overnight
  2. filtrationfiltered
  3. customthe filtrate was evaporated
  4. custompurified on silica gel column

Sources & evidence

ORD record
ord-2a1f931bc48f4510bf36435f4fabf701
Source dataset
uspto-grants-2011_07
Patent number
US07977346B2

Reaction notes

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