Trifluoroacetic acid → HCID 178446274, compound

HRID 1010954Notes

Reaction equation

HRID 1010954 reaction equation
[CH3:1][O:2][C:3]1[N:4](C2CCCCO2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:6]=2.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][O:2][C:3]1[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:6]=2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57699747HCID 57699747, compound

Product 1

HCID 178446274HCID 178446274, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 8-methoxy-N2-pentyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine (520 mg) in dry MeOH (5.2 mL) was added TFA (0.52 mL) and the mixture was stirred at room temperature for 48 h. The reaction was concentrated in vacuo to give an orange residue which was triturated with Et2O and filtered to give the title compound as an off-white solid (223 mg).

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give an orange residue which
  3. customwas triturated with Et2O
  4. filtrationfiltered

Sources & evidence

ORD record
ord-c38fed701d144901b62f19917eeca3e5
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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