Trifluoroacetic acid → HCID 178447008, compound

HRID 1010964Notes

Reaction equation

HRID 1010964 reaction equation
[CH3:1][CH:2]([CH2:23][CH3:24])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:20][CH3:21])[N:11]2C2CCCCO2)=[C:7]([NH2:22])[N:6]=1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>CO>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[CH3:1][CH:2]([CH2:23][CH3:24])[CH2:3][O:4][C:5]1[N:13]=[C:12]2[C:8]([N:9]=[C:10]([O:20][CH3:21])[NH:11]2)=[C:7]([NH2:22])[N:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57699821HCID 57699821, compound

Product 1

HCID 178447008HCID 178447008, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-[(2-methylbutyl)oxy]-8-methoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (199 mg) in dry MeOH (1.99 mL) was added TFA (0.199 mL). The mixture was stirred at room temperature for 24 h. The reaction was concentrated in vacuo to give a yellow residue. The residue was triturated with Et2O and was filtered to give the title compound as an off-white solid (111 mg).

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give a yellow residue
  3. customThe residue was triturated with Et2O
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-e4a2718aad824f70bb29fccfd6bd691c
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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