Ammonia → HCID 178509092, compound

HRID 1010972Notes

Reaction equation

HRID 1010972 reaction equation
[Cl:1][C:2]1[NH:3][C:4](Cl)=[C:5]2[C:9]([N:10]=1)=[N:8][CH:7]=[N:6]2.[NH3:12]>C(O)(C)C>[Cl:1][C:2]1[NH:3][C:4]([NH2:12])=[C:5]2[C:9]([N:10]=1)=[N:8][CH:7]=[N:6]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178478323HCID 178478323, compound

Product 1

HCID 178509092HCID 178509092, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 2,6-dichloro-1H-purine (5 g) and ammonia solution (79.2 mL, 2M in (isopropanol) was stirred and heated at 120° C. in an autoclave overnight. The reaction was cooled and concentrated in vacuo to give the title compound as an off-white solid in quantitative yield.

Workup

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-0dc9f4da72324df487aaf546fdb439b4
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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