Trifluoroacetic acid → HCID 178495541, compound

HRID 1011007Notes

Reaction equation

HRID 1011007 reaction equation
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[CH3:8][CH:9]([O:13][C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([O:29][CH3:30])[N:20]2C2CCCCO2)=[C:16]([NH2:31])[N:15]=1)[CH2:10][O:11][CH3:12]>CO>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[CH3:8][CH:9]([O:13][C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([O:29][CH3:30])[NH:20]2)=[C:16]([NH2:31])[N:15]=1)[CH2:10][O:11][CH3:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 576997482-{[1-methyl-2-(methoxy)ethyl]oxy}-8-(methoxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Product 1

HCID 178495541HCID 178495541, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

TFA (7.5 ml) was added to a solution of 2-{[1-methyl-2-(methoxy)ethyl]oxy}-8-(methoxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (4.7 g, 13.9 mmol) in MeOH (30 ml) with stirring. The mixture was left to stand at room temperature for 1 day. A white solid formed which was filtered off and washed with ethyl acetate. This gave product (3.7 g, 76.1%)

Workup

  1. waitThe mixture was left
  2. customA white solid formed which
  3. filtrationwas filtered off
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-84b347f393bc44c7b96f208e84d7e23f
Source dataset
uspto-grants-2011_07
Patent number
US07977344B2

Reaction notes

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