Boron trifluoride → HCID 87318249, compound

HRID 1011221Notes

Reaction equation

HRID 1011221 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:9]2[O:13][CH2:14][CH:15]([CH3:16])[N:7]3[C:8]=2[C:3]=1[C:4](=[O:20])[C:5]([C:17]([OH:19])=[O:18])=[CH:6]3.[B:21](F)([F:23])[F:22]>>[B:21]([F:23])([F:22])[O:18][C:17]([C:5]1[C:4](=[O:20])[C:3]2[C:8]3=[C:9]([O:13][CH2:14][CH:15]([CH3:16])[N:7]3[CH:6]=1)[CH:10]=[C:11]([F:12])[C:2]=2[F:1])=[O:19]

Participants

3

Reactant 2

HCID 6356Boron trifluorideHCID 67234273HCID 67234273, compound

Product 1

HCID 87318249HCID 87318249, compound

Procedure

From 1.0 g of 8,9-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (for preparation see Journal of Medicinal Chemistry 1992, 35 (4), 611) and 1.51 g (3 eq.) of BF3 etherate, by the same method as described for Example 38A, 1.0 g (85% of theory) of the title compound is isolated.

Sources & evidence

ORD record
ord-02c1b1ccdc124bb5bc508dc6b8bbead1
Source dataset
uspto-grants-2011_07
Patent number
US07977349B2

Reaction notes

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