Morpholine → HCID 67315548, compound

HRID 1011394Notes

Reaction equation

HRID 1011394 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[CH:12][C:11]2[C:14](=[C:19]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[NH:21][C:20]3=[O:28])[O:15][CH:16]([CH2:17][CH3:18])[C:10]=2[CH:9]=1>C(O)(C)C>[CH2:17]([CH:16]1[C:10]2[CH:9]=[C:8]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)[N:13]=[CH:12][C:11]=2[C:14](=[C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][C:20]2=[O:28])[O:15]1)[CH3:18]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 76798884HCID 76798884, compound

Product 1

HCID 67315548HCID 67315548, compoundYield 54.1%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of morpholine (200 mg, 2.29 mmol) in 4 mL of isopropanol is treated with 3-(6-Chloro-1-ethyl-1H-furo[3,4-c]pyridin-3-ylidene)-1,3-dihydro-indol-2-one (100 mg, 0.31 mmol) in one portion and the reaction mixture is heated to reflux for 72 h. The reaction mixture is cooled to room temperature and the solid which precipitated from solution is collected by filtration and dried to give the title compound as a yellow solid (61 mg, 54%).

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureto reflux for 72 h
  3. customthe solid which precipitated from solution
  4. filtrationis collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-b7bbc1256263446daffa3e781b4068db
Source dataset
uspto-grants-2011_07
Patent number
US07977351B2

Reaction notes

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