Sodium Methoxide → HCID 14837017, compound

HRID 1011437Notes

Reaction equation

HRID 1011437 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH3:12][O-:13].[Na+]>CN(C=O)C>[CH3:12][O:13][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 111279913-Bromo-5-(trifluoromethyl)pyridine

Product 1

HCID 14837017HCID 14837017, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 3-bromo-5-trifluoromethylpyridin (2.25 g 10 mmol, prepared as described in Eur. J. Org. Chem. 2002, 327-330, in DMF was added sodium methoxide (0.8 g, 15 mmol). The resultant solution is stirred for 20 hours at 40° C. The title compound is obtained after evaporation of the solvent under vacuum.

Sources & evidence

ORD record
ord-e6acd3dd604048d7943ed3a728da25f3
Source dataset
uspto-grants-2011_07
Patent number
US07977354B2

Reaction notes

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