Pyrrolidine → HCID 25002216, compound

HRID 1011578Notes

Reaction equation

HRID 1011578 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:6][C:7]([NH:9][C:10]1[NH:11][C:12]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH2:25][CH2:26][CH2:27]Cl)=[CH:13][C:14]=1[C:15]([NH2:17])=[O:16])=[O:8]>>[NH2:6][C:7]([NH:9][C:10]1[NH:11][C:12]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH2:25][CH2:26][CH2:27][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:13][C:14]=1[C:15]([NH2:17])=[O:16])=[O:8]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 59285987HCID 59285987, compound

Product 1

HCID 25002216HCID 25002216, compoundYield 42%

Conditions

Temperature
120 °C

Procedure

Pyrrolidine (0.5 mL) was added to 2-aminocarbonylamino-5-[2-(3-chloropropyloxy)phenyl]pyrrole-3-carboxamide (Compound No. 4-29, 30 mg, 0.090 mmol), the whole was sealed and stirred at 120° C. for 5 hours. This mixture was purified by silica gel column chromatography to give the target compound (14 mg) as a brown amorphous Powder (Yield 42%).

Workup

  1. custom4-29, 30 mg, 0.090 mmol), the whole was sealed
  2. customThis mixture was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-d26a0cb45c5d4237aeebcf4a586b5078
Source dataset
uspto-grants-2011_07
Patent number
US07977371B2

Reaction notes

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