Hydrochloric Acid → HCID 178519992, compound

HRID 1011614Notes

Reaction equation

HRID 1011614 reaction equation
[Si]([O:8][CH2:9][CH:10]1[C:14]2=[N:15][NH:16][CH:17]=[C:13]2[C@@H:12]([CH:18]2[CH2:20][CH2:19]2)[N:11]1C(OC(C)(C)C)=O)(C(C)(C)C)(C)C.Cl>O1CCOCC1>[CH:18]1([C@@H:12]2[C:13]3[C:14](=[N:15][NH:16][CH:17]=3)[CH:10]([CH2:9][OH:8])[NH:11]2)[CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452487HCID 178452487, compound

Product 1

HCID 178519992HCID 178519992, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(4R)-tert-butyl 6-((tert-butyldimethylsilyloxy)methyl)-4-cyclopropyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate (35) (1.38 g, 3.51 mmol) was covered with HCl in dioxane (4 N, 5 mL).). The reaction mixture was stirred at rt for 1 hr after which it was concentrated under vacuum to give ((4R)-4-cyclopropyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-6-yl)methanol (36). Retention time (min)=0.203, method [1], MS (m/z) 180.2 (M+H)+.

Workup

  1. concentrationwas concentrated under vacuum

Sources & evidence

ORD record
ord-c09574e1c4ab47ea9e272acd980d9108
Source dataset
uspto-grants-2011_07
Patent number
US07977368B2

Reaction notes

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