反应详情

A mixture of 4-bromo-2-fluorobenzaldehyde (12.4 g, 61 mmol), malonic acid (12.7 g, 122 mmol) and 4-dimethylamino pyridine (0.75 g, 6.1 mmol) in 20 mL of DMF was heated at 100 degrees Celsius for 2 hrs. After cooling, the reaction mixture was diluted with 300 mL water, and filtered. The solid was collected, and triturated in hexane. The solid was collected and dried in vacuum to give 12.7 g (85%) of a white solid. MS: calc'd 243 (M−H), exp 243 (M−H).

1. temperaturewas heated at 100 degrees Celsius for 2 hrs
2. temperatureAfter cooling
3. filtrationfiltered
4. customThe solid was collected
5. customtriturated in hexane
6. customThe solid was collected
7. customdried in vacuum