反应详情

In analogy to the procedure described in example 16A], 4-(3-bromo-phenyl)-3-methyl-2,4-dioxo-butyric acid ethyl ester (synthesized from 3′-bromopropiophenone and diethyl oxalate, following a procedure described in Ksander, Gary M.; McMurry, John E.; Johnson, Mark. A method for the synthesis of unsaturated carbonyl compounds. Journal of Organic Chemistry (1977), 42(7), 1180-5) and hydrazine monohydrate were heated at 90° C. in EtOH for 1 h to give after crystallization (Et2O/n-penatane) the title compound in 46% yield as off-white powder. MS: 308.1 (M+, 1 Br).

1. customto give
2. customafter crystallization (Et2O/n-penatane) the title compound in 46% yield as off-white powder