1-Chloro-4-iodobenzene → HCID 178463853, compound

HRID 1011927Notes

Reaction equation

HRID 1011927 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[CH2:9]([N:11]([CH2:33][CH3:34])[CH:12]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[C:23]([CH3:24])=[C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([C:31]#[CH:32])[CH:26]=3)[NH:21][N:20]=2)=[O:18])[CH2:13]1)[CH3:10]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:32]#[C:31][C:27]2[CH:26]=[C:25]([C:22]3[NH:21][N:20]=[C:19]([C:17]([N:14]4[CH2:15][CH2:16][CH:12]([N:11]([CH2:33][CH3:34])[CH2:9][CH3:10])[CH2:13]4)=[O:18])[C:23]=3[CH3:24])[CH:30]=[CH:29][CH:28]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 125101-Chloro-4-iodobenzeneHCID 178436202(3-Diethylamino-pyrrolidin-1-yl)-[5-(3-ethynyl-phenyl)-4-methyl-1H-pyrazol-3-yl]-methanone

Product 1

HCID 178463853HCID 178463853, compoundYield 74%

Procedure

In analogy to the procedure described in Example 31F], 1-chloro-4-iodobenzene and (3-diethylamino-pyrrolidin-1-yl)-[5-(3-ethynyl-phenyl)-4-methyl-1H-pyrazol-3-yl]-methanone (Example 31E]) gave the title compound in 74% yield light yellow powder. MS: 461.1 (MH+, 1 Cl).

Sources & evidence

ORD record
ord-f200f8649c6a4c20b5df8e9f1d76f86a
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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