Hydrochloric Acid → HCID 67314549, compound

HRID 1012014Notes

Reaction equation

HRID 1012014 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C@@H:11]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:10][C@@H:9]1[CH3:19])=O)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[CH3:19][C@H:9]1[CH2:10][C@H:11]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[CH2:12][CH2:13][NH:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86626596HCID 86626596, compound

Product 1

HCID 67314549HCID 67314549, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Treatment of (trans) 2-methyl-4-pyrrolidin-1-yl-piperidine-1-carboxylic acid tert-butyl ester (0.1 g, 0.4 mmol) with 4M hydrochloric acid in dioxane (5 ml) for 1 h and subsequent evaporation of the solvent afforded the title compound (0.06 g, 84%) as a white powder. MS: 169.1 (MH+).

Workup

  1. customsubsequent evaporation of the solvent

Sources & evidence

ORD record
ord-8d8a967eea7e40649871b86188cbfa17
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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