Hydrochloric Acid → HCID 67315126, compound

HRID 1012017Notes

Reaction equation

HRID 1012017 reaction equation
C[O:2][C:3]([CH:5]1[N:9](C(OC(C)(C)C)=O)[CH2:8][CH:7]([N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:6]1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[ClH:28]>O1CCOCC1>[ClH:28].[ClH:28].[N:17]1([C@H:7]2[CH2:6][C@@H:5]([CH2:3][OH:2])[NH:9][CH2:8]2)[CH2:18][CH2:19][CH2:20][CH2:21]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21226445Aluminium lithium hydrideHCID 698173511′-(1,1-Dimethylethyl) 5′-methyl [1,3′-bipyrrolidine]-1′,5′-dicarboxylate

Product 1

HCID 67315126HCID 67315126, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared in analogy to 193B, by reduction of 3′S,5′S)-[1,3′]Bipyrrolidinyl-1′,5′-dicarboxylic acid 1′-tert-butyl ester 5′-methyl ester with lithium aluminium hydride and subsequent deprotection with 4M hydrochloric acid in dioxane. MS: 171.3 (MH+).

Sources & evidence

ORD record
ord-5cddac67714a401a9b26586084fd352a
Source dataset
uspto-grants-2011_07
Patent number
US07977358B2

Reaction notes

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