1-Methylpiperazine → HCID 178463842, compound

HRID 1012038Notes

Reaction equation

HRID 1012038 reaction equation
Cl[C:2]1[N:3]=[C:4](/[N:19]=[N:20]/[C:21]2[CH:26]=[CH:25][C:24]([N:27]([CH2:30][CH3:31])[CH2:28][CH3:29])=[CH:23][CH:22]=2)[S:5][C:6]=1[CH:7]=[C:8]1[C:16](=[O:17])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18].[CH3:32][N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>O1CCCC1>[CH2:28]([N:27]([CH2:30][CH3:31])[C:24]1[CH:25]=[CH:26][C:21](/[N:20]=[N:19]/[C:4]2[S:5][C:6]([CH:7]=[C:8]3[C:16](=[O:17])[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[C:9]3=[O:18])=[C:2]([N:36]3[CH2:37][CH2:38][N:33]([CH3:32])[CH2:34][CH2:35]3)[N:3]=2)=[CH:22][CH:23]=1)[CH3:29]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 178463841HCID 178463841, compound

Product 1

HCID 178463842HCID 178463842, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.00 g (2.20 mmol) 2-[(4-chloro-2-{(E)-[4-(diethylamino)phenyl]diazenyl}-1,3-thiazol-5-yl)methylene]-1H-indene-1,3(2H)-dione and 0.30 g (2.70 mmol) 1-methylpiperazine were dissolved in 40 ml tetrahydrofurane (THF) and heated under stirring for 5 hours when thin layer chromatography (TLC) analysis indicated complete consumption of the starting material. After cooling to room temperature the formed precipitate was filtered off, washed with THF and dried in vacuum at 40° C. to obtain a dark green powder.

Workup

  1. temperatureheated
  2. customconsumption of the starting material
  3. filtrationwas filtered off
  4. washwashed with THF
  5. customdried in vacuum at 40° C.
  6. customto obtain a dark green powder

Sources & evidence

ORD record
ord-da225ae800a34e9fac61a582e8010377
Source dataset
uspto-grants-2011_07
Patent number
US07977482B2

Reaction notes

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