Dimethylformamide → HCID 13755128, compound

HRID 1012365Notes

Reaction equation

HRID 1012365 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.Cl[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1.C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 79772-ChloropyridineHCID 11430Potassium CarbonateHCID 2401474-Mercaptophenol

Product 1

HCID 13755128HCID 13755128, compoundYield 91.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
75 °C

Procedure

Under nitrogen atmosphere, 127 g of 4-hydroxythiophenol, 112 g of chloropyridine, and 140 g of potassium carbonate were mixed. To the mixture was added 250 mL of dimethylformamide. The resultant was stirred, heated to 75° C. and further heated at 10° C. for 5 hours. At the time when the reaction completed substantially, the resultant was poured into 1.5 L of water. The precipitated crystals were collected by filtration, washed with water, and dried (yielded amount 184 g, and yield 91.8%).

Workup

  1. temperaturefurther heated at 10° C. for 5 hours
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customdried
  5. custom(yielded amount 184 g, and yield 91.8%)

Sources & evidence

ORD record
ord-5dd5d184f989464d9eadc6cd5e7e064f
Source dataset
uspto-grants-2011_07
Patent number
US07977491B2

Reaction notes

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