Triethylamine → HCID 2846630, compound

HRID 1012911Notes

Reaction equation

HRID 1012911 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][N:12]1[CH2:17][CH2:16][CH:15]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH2:14][CH2:13]1.C(N(CC)CC)C>C(O)(C)C.O>[CH3:11][N:12]1[CH2:13][CH2:14][CH:15]([N:18]2[CH2:23][CH2:22][N:21]([C:2]3[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=3)[CH2:20][CH2:19]2)[CH2:16][CH2:17]1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 9590p-FluoronitrobenzeneHCID 5663241-(1-Methyl-4-piperidinyl)piperazine

Product 1

HCID 2846630HCID 2846630, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

4-Fluoronitrobenzene (3 g, 21.3 mmol), 1-(1-methylpiperidin-4-yl)piperazine (3.9 g, 21.2 mmol) and triethylamine (3.30 mL, 23.7 mmol) are stirred in anhydrous isopropanol (10 mL) for 10 min at 160° C. in the microwave. The reaction mixture is diluted with water (10 mL), the precipitate is filtered off washed with 50% water in isopropanol and dried in vacuo at 45° C. Yield: 5.14 g

Workup

  1. filtrationthe precipitate is filtered off
  2. washwashed with 50% water in isopropanol
  3. customdried in vacuo at 45° C

Sources & evidence

ORD record
ord-446f57b1a6094709ae895cfdaef03a53
Source dataset
uspto-grants-2011_07
Patent number
US07981880B2

Reaction notes

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