反应详情

温度

80 °C

A mixture of (4-methoxy-benzothiazol-2-yl)-piperidin-4-yl-methanone (83 mg, 0.3 mmol), 6-oxiranyl-2,3-dihydro-benzo[1,4]dioxine (53.5 mg, 0.3 mmol), lithium perchlorate (32 mg, 0.3 mmol) and potassium carbonate (42 mg, 0.3 mmol) in DMF (2 ml) was heated at 80° C. overnight. The mixture was poured on water and extracted with EtOAc. Organic extracts were washed with water and brine, dried over MgSO4 and concentrated. Chromatography on SiO2 (EtOAc/MeOH 9:1) gave the title compound as a beige solid (100 mg, 73%, 4:1 mixture of regioisomers).

1. additionThe mixture was poured on water
2. extractionextracted with EtOAc
3. washOrganic extracts were washed with water and brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated