反应详情

To a solution of 4-(3-amino-benzyl)-5,6,7,8-tetrahydro-2H-phthalazin-1-one (4) (0.472 mg, 1.850 mmol) in dry THF (25 ml) was added a solution of ethyl 2-isocyanopropionate (266 mg, 1.850 mmol) in 2 ml of THF. The resultant solution was then stirred for 4 hours and then concentrated in vacuo to afford a brown oil. The crude oil was subjected to flash chromatography eluent 4:1, hexane:ethyl acetate. (Rf=0.14 neat ethyl acetate). Main peak in LC-MS, (7.20 g, 98% purity); m/z (LC-MS, ESP), RT=3.20 mins (M+H 389.4).

1. concentrationconcentrated in vacuo
2. customto afford a brown oil