1-(Thiophen-3-yl)ethanone → HCID 5373947, compound

HRID 1013100Notes

Reaction equation

HRID 1013100 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6](=[O:8])[CH3:7])=[CH:2]1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:11][N:12]([CH3:14])/[CH:13]=[CH:7]/[C:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)=[O:8]

Participants

3

Reactant 2

HCID 151161-(Thiophen-3-yl)ethanoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 5373947HCID 5373947, compoundYield 70.1%

Procedure

Stir 1-thien-3-ylethanone (1.26 g, 10 mmol) with N,N-dimethylformamide dimethyl acetal (2.66 mL, 20 mmol) at reflux for 4 h. Cool to RT, concentrate and dry in a vacuum oven to give the title compound as a brown solid (1.27 g, 70%).

Workup

  1. temperatureat reflux for 4 h
  2. concentrationconcentrate
  3. customdry in a vacuum oven

Sources & evidence

ORD record
ord-dc71ff4a4034483494dba1dce70d4903
Source dataset
uspto-grants-2011_07
Patent number
US07981882B2

Reaction notes

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