HCID 131729025, compound → HCID 59789449, compound

HRID 1013352Notes

Reaction equation

HRID 1013352 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:13][CH:12]2[CH:8]([CH2:9][C:10]3[CH:16]=[C:15]([CH2:17]O)[S:14][C:11]=32)[CH2:7]1)=[O:5])[CH3:2]>CCOC(C)=O.[Pd]>[CH2:1]([O:3][C:4]([N:6]1[CH2:13][CH:12]2[CH:8]([CH2:9][C:10]3[CH:16]=[C:15]([CH3:17])[S:14][C:11]=32)[CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 131729025HCID 131729025, compound

Product 1

HCID 59789449HCID 59789449, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The product of step b) was dissolved in EtOAc (50 ml) and 10% Pd/C (1 gram) was added. The flask was evacuated and purged four times with N2 and then a balloon of H2 was added and the reaction was stirred for 24 hours at room temperature. Next, the mixture was passed through a pad of celite and the solvent was concentrated providing the subtitled product that was used without further purification.

Workup

  1. customThe flask was evacuated
  2. custompurged four times with N2
  3. additiona balloon of H2 was added
  4. concentrationthe solvent was concentrated

Sources & evidence

ORD record
ord-eeadfd946288456baebf5ab8c718dbae
Source dataset
uspto-grants-2011_07
Patent number
US07981919B2

Reaction notes

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