Hydrochloric Acid → HCID 57925887, compound

HRID 1013451Notes

Reaction equation

HRID 1013451 reaction equation
C([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11](CP(=O)O)=[CH:10][CH:9]=1)=[O:7])(C)(C)C.[CH2:18]([O:20][P:21]([C:24]1[CH:36]=[CH:35][C:27](C(OC(C)(C)C)=O)=[CH:26][CH:25]=1)(C)=[O:22])C.[OH-].[K+].Cl>O1CCOCC1>[CH3:18][O:20][P:21]([C:11]1[CH:10]=[CH:9][C:8]([C:6]([OH:5])=[O:7])=[CH:13][CH:12]=1)([C:24]1[CH:36]=[CH:35][CH:27]=[CH:26][CH:25]=1)=[O:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 86635269HCID 86635269, compoundHCID 178450701HCID 178450701, compound

Product 1

HCID 57925887HCID 57925887, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

[4-(tert-Butoxycarbonyl)phenyl]methylphosphinic acid]. tert-Butyl 4-[ethoxy(methyl) phosphoryl]benzoate (510 mg, 1.79 mmol) was made 0.25 M in dioxane and to this stirring solution was added potassium hydroxide (5.38 mL, 5.38 mmol). The resulting mixture was stirred at ambient temperature for 10 minutes. The reaction mixture was neutralized with 1 eq aq HCl then concentrated in vacuo. The residue was diluted with MeOH, the inorganic salts were filtered off and the filtrate was concentrated in vacuo. MS: cal'd 257 (MH+), exp 257 (MH+).

Workup

  1. concentrationthen concentrated in vacuo
  2. additionThe residue was diluted with MeOH
  3. filtrationthe inorganic salts were filtered off
  4. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-818630fb9f374a8fb6b59293ea09848c
Source dataset
uspto-grants-2011_07
Patent number
US07981874B2

Reaction notes

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