反应详情

Heat a solution of 3-chloro-4-methylphenol (15 g, 0.11 mol), iodomethane (9.8 mL, 0.16 mol), and potassium carbonate (22 g, 0.16 mol) in DMF (200 mL) to 50° C. and stir for 2 hr. Cool the reaction to room temperature and quench with 1N aqueous HCl. Extract the aqueous with diethyl ether (Et2O). Wash the organic with brine, dry over MgSO4, and filter. Remove the solvent to afford 16.4 g (100%) of the desired product.

1. temperatureCool
2. customthe reaction to room temperature
3. customquench with 1N aqueous HCl
4. extractionExtract the aqueous with diethyl ether (Et2O)
5. washWash the organic with brine
6. dry with materialdry over MgSO4
7. filtrationfilter
8. customRemove the solvent