Sodium Iodide → HCID 86629984, compound

HRID 1013798Notes

Reaction equation

HRID 1013798 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([F:12])=[C:4]([F:13])[C:3]=1[CH2:14]Cl.[I-:16].[Na+]>CC(C)=O.CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([F:12])=[C:4]([F:13])[C:3]=1[CH2:14][I:16]

Participants

5

Reactant 2

HCID 5238Sodium IodideHCID 44717492HCID 44717492, compound

Product 1

HCID 86629984HCID 86629984, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 8857Ethyl AcetateSolvent

Procedure

Treat a solution of 1-chloro-2-chloromethyl-3,4-difluoro-5-trifluoromethyl-benzene (1.0 g, 3.8 mmol) in acetone (10 mL) with sodium iodide (2.8 g, 19 mmol) and stir the reaction 1 hr at room temperature. Dilute the reaction in EtOAc (50 mL) and filter. Concentrate the filtrate to afford 1.35 g (100%) of product. 1H NMR (d6-CDCl3) δ 7.39 (d, 1H, J=5.7 Hz), 4.46 (d, 2H, J=2.2 Hz).

Workup

  1. customthe reaction 1 hr at room temperature
  2. additionDilute
  3. filtrationfilter
  4. concentrationConcentrate the filtrate

Sources & evidence

ORD record
ord-5403b7c2ea024eadaefd497806d6545c
Source dataset
uspto-grants-2011_07
Patent number
US07981918B2

Reaction notes

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